This presentation describes a research program at the Center for Alaska Native Health Research in the Institute of Arctic Biology based on exploring Yup’ik youth resilience strategies in an effort to inform and develop effective interventions that address disparities in youth suicide and substance abuse. This program is based on over a decade of community-based participatory research (CBPR) collaborations between researchers at UAF and Yup’ik Tribal communities and organizations. This presentation will describe the development of this collaborative and participatory research relationship and identify process outcomes of implementing a Tribal and youth participatory approach for one community in Southwest Alaska. This program receives support from the NIH/National Institute of Minority Health and Health Disparities, the National Science Foundation and the State of Alaska.