A roundtable discussion of how the study of ancient pathogen DNA intersects with the study of disease in late antiquity. Can laboratory scientists and cultural historians find ways to interface given their different methods, data, concepts, and conclusions? The discussion was organized by Tina Sessa (The Ohio State University) and Tim Newfield (Georgetown University), and moderated by Dionysios Stathakopoulos (University of Cyprus). In addition to Tina and Tim, participants include Kyle Harper (University of Oklahoma), Marcel Keller (University of Basel and University of Tartu), and Maria Spyrou (University of Tübingen). A transcript of the discussion will appear in the journal Studies in Late Antiquity.