Natasha Leggero shares what she loves about John Waters, walks through the development of her onstage persona and bonds with Anthony over not telling self-effacing jokes.

Tig Notaro reveals what she does when she bombs onstage, does her impression of Joan Rivers and Larry David’s baby, and names her least favorite comedian.

Kumail Nanjiani chats about the differences between acting and stand-up, gets quizzed on lines from his movies and offers insight into a pivotal scene from “The Big Sick.”

David Spade explains what makes stand-up more difficult today, chats about steering clear of political jokes and considers how his childhood influenced his comedy.

Kristen Schaal recalls winning an alternative comedy award, debates with Anthony about how important surprise is to comedy and reflects on her experiences as a new mother.

Nick Kroll talks about how “Big Mouth” came to be, fawns over “Wayne’s World” and plays the game Actual Turtle or Turtle from “Entourage”? with Anthony. 

In his return to television, Anthony Jeselnik interrogates and takes s**t from his friends and fellow comedians, such as David Spade, Nick Kroll, Natasha Leggero, Kristen Schaal, Tig Notaro and Kumail Nanjiani.