Dr Glenn McConell chats with Professor Pope Moseley from Arizona State University in the United States. Pope has a lung and critical care background. We spoke about his early heat shock protein work with Carl Gisolfi, a giant of research on exercise and the gut. Also heat, heat shock proteins, gut leak and heat stroke, exercise training and gut leak, heat shock proteins and autophagy, “Heat shock proteins are how cells think”, heat related illness is only a fraction of disease driven by heat. After a serious acute back injury requiring back surgery, Pope found Kettlebells to be very useful (we discussed the person who introduced kettlebells to the west, Pavel Tsatsouline). 0:00. Introduction and Pope’s running and medical background4:49. Heat shock proteins and exercise (with Carl Gisolfi)9:45. Exercise and the heat legend: John Sutton12:14. Cognitive effects of heat exhaustion after exercise13:56. John Sutton papers brilliant14:40. Heat, heat shock proteins and gut leak19:15. Exercise training makes the gut less leaky21:10. Heat stroke can be due to gut barrier breakdown22:44. Chris Leigh, exertional heat stroke and the gut24:14. Bente Klarlund Pedersen and Bengt Saltin28:47. Interactions between heat shock proteins and autophagy32:40. Heat shock proteins as chaperones34:00. Heat shock proteins, autophagy and exercise36:46. Exercise, exercise training and heat shock protein38:01. Heat related illness only a fraction of disease driven by heat44:15. Can exercise reduce the likelihood of heat related illness?47:02. Denmark and equality, health care access, tax etc50:57. Pope’s back injury and emergency surgery54:50. Introduction to Kettlebells and his certification etc56:10. Kettlebells and Pavel Tsatsouline58:55. Pavel Tsatsouline, interval training and stroke volume1:04:05. Grip strength, getting up from the floor and posture1:08:04. Pope’s kettlebell Instagram1:10:18. Working on heat in Phoenix Arizona1:11:40. Pope doing the Tactical strength challenge1:13:56. Viruses take over heat shock proteins1:17:45. Takeaway messages1:18:18. Outro (9 secs) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University. He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9). Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: [email protected] Subscribe to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice