Dr Glenn McConell chats with Professor Mark Tarnopolsky from McMaster University in Canada. Mark has done pioneering studies in many areas including sex differences and exercise, HITT training and creatine supplementation. Today we focus on his remarkable work with muscle myopathies. Exercise can be beneficial in all muscle myopathies in regards to function and/or healthspan and/or lifespan. The type of exercise will differ depending on the myopathy: endurance, resistance, or both.0:00. Introduction and overview of Mark’s exercise, clinical and research4:45. McMaster University: Stu Phillips, Marty Gibala and Mark6:30. His sex differences and exercise research8:06. Exosomes re drug delivery and exercise15:48. Types of muscle myopathies19:39. Exercise can improve McArdles disease24:29. Weight training, creatine and McArdles disease28:20. Exercise and glycoytic defects, glucose ingestion/fasting30:53. Creatine phosphate34:50. Rhabdomyolysis39:53. Mark’s very impressive sporting background and lab numbers41:45. Mark’s cardiac ablations42:48. The heart and VO2 max etc43:49. Mitochondrial disease and exercise/RER48:30. Ex training increases VO2 max in mitochondrial disease51:00. Most common mitochondrial diseases53:20. How does exercise improve exercise in mitochondrial diseases55:00. Muscle affected in different genetic deficits57:26. Neuromuscular junction with Dr Tarnopolsky on YouTube58:17. Exercise beneficial with pretty much every muscle disease58:40. Exercise improves strength in Inclusion body myopathy58:50. Exercise improves function etc in muscular dystrophy59:5 Pompe disease. Exercise better than $1million/yr treatment1:01:18. Tends to be focus on pharma despite exercise being better1:03:35. Duchenne muscular dystrophy, exercise and life expectancy1:09.02. Resistance vs strength vs both in muscle defects1:11:38. Different resistance training tactics in mitochondrial patients1:13:02. Creatine and other supplements in muscle defects1:16:29. Study designs, funding,patents etc1:18:07. Do people who don’t have muscle myopathies need supplements?1:19:11. Disclosure: Founder and CEO of the Exerkine Company1:21:40. “Exercise the best supplement”1:23:59. Exokines within exosomes not that useful so far1:28:24. Take away messages1:31:42. Mark’s running ability/injuries as age etc.1:33:57. Mark’s injuries/diet/supplements1:36:54. Outro (9 seconds) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: [email protected] to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice.Disclosure: Prof Tarnopolsky is the Founder and CEO of the Exerkine Company.