Dr Glenn McConell chats with Dr Paul Cohen from Translational Research Institute for Metabolism and Diabetes, AdventHealth Orlando, Florida, USA. He has a very strong track record of research examining muscle mitochondria in health and disease and in particular the effects of exercise in attenuating the reductions in mitochondrial function with age. A very interesting chat. Twitter: @CoenPM 0:00. Introduction/Paul’s exercise research training 3:10. Exercise, aging and inflammation markers etc 5:55. Bret Goodpaster/Advent Health 8:53. Muscle mitochondria functions 10:15. Mitochondria: energetics, function, biogenesis 13:11. Effects of aging on mitochondria 16:15. Mitochondria energetics, VO2 max and muscle power with age 22:30. Isolated mito vs fibers vs in vivo measures of mito 24:52. Changes with aging per se vs inactivity with aging 28:40. Can mimic exercise using isolated mito measures? 32:03. Time course of mito changes with age vs physical activity 34:00. Is walking enough to maintain mitochondrial volume etc? 35:40. The body and the response to exercise is very integrative 37:25. Lipids in muscle and mitochondrial function 39:00. Subcellular vs intramyofibullar mitochondria 42:55. Mitochondrial energetics and mobility as age etc 44:45. Medications vs exercise 46:08. Aging, mitochondria respiration and leg power 47:40. Aging, mitochondrial energetics and fatigue 49:10. Sex differences in mitochondrial energetics 50:25. Aging vs physical inactivity with aging 52:00. Aging, mitochondria, gait speed and mortality 54:08. If do one thing best to do aerobic or weight training? 56:12. The best exercise is the exercise that people will do 56:10. Social interaction 57:20. Exercise for health span vs life span/“Stop aging” 1:00:12. Healthy aging when have a well managed disease? 1:01:52. Markers of healthy aging 1:03:05. Inherited and acquired mito DNA sequence variations 1:06:10. Nitrate supplementation, mitochondria and aging 1:09:05. Bed rest, diabetes, muscle mass and mitochondrial 1:13:15. Takeaway messages 1:14:43. Links between mitochondrial function and insulin sensitivity? 1:18:43. Outro (9 seconds) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University. He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9). Connect with Inside Exercise and Glenn McConell at: Twitter: @Inside_exercise and @GlennMcConell1 Instagram: insideexercise Facebook: Glenn McConell LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460 ResearchGate: Glenn McConell Email: [email protected] Subscribe to Inside exercise: Spotify: shorturl.at/tyGHL Apple Podcasts: shorturl.at/oFQRU YouTube: https://www.youtube.com/@insideexercise Anchor: https://anchor.fm/insideexercise Google Podcasts: shorturl.at/bfhHI Anchor: https://anchor.fm/insideexercise Podcast Addict: https://podcastaddict.com/podcast/4025218 Not medical advice