Dr Glenn McConell chats with Associate Professor Chris Fry from the University of Kentucky, USA. Joint injury causes muscle weakness and atrophy (reductions in muscle size) due to the the inactivity but also separately due to the injury itself. Substances are released from muscle to help repair the joint/bone. Prehab is important before surgery. There can be residual effects long after joint injury. We also discussed hypertrophy and aging and the importance of having a lot of muscle capillaries as age to obtain the optimum response to resistance training. Lots more. We had a really great chat. Chris has a very pleasant manner. I enjoyed it a lot. Twitter: @ChrisFryPhD0:00. Introduction and welcome3:09. How Chris got into exercise research6:10. ACL injuries and muscle wasting /weakness9:05. Joint injuries and the risk of arthritis10:05. The effects of the inactivity vs the injury itself13:55. Protein synthesis vs breakdown after an ACL injury19:30. Why in evolutionary sense does joint injury result in muscle atrophy22:50. What are the signals to cause muscle atrophy24:00. Myostatin release after joint injury26:55. Acute vs chronic injury28:15. Other joint injuries to joints (other than ACL)29:25. Atrophy in different muscle fibre types31:15. Best way to prepare for surgery after an injury34:05. How quickly start rehab after surgery35:45. Are there residual effects long after joint injury?39:55. Bone vs joint injury43:30. Muscle reactive oxygen species/ mitochondria after injury46:05. Aerobic capacity of muscle still reduced after rehab47:05. Should take anti inflammatories after injury?49:20. Vitamin D and muscle injury52:15. Does joint injury affect muscle in the non injuried limb?54:45. What can do to slow atrophy after injury?55:55. Does muscle size and strength go hand in hand after injury57:15. Time since injury/trauma and surgery58:55. Sex difference and joint injury1:00:20. Age and joint injuries1:01:10. Hypertrophy and aging1:02:05. Aging: inactivity vs training response1:03:00. More capillaries in muscle increases response to resistance training1:05:00. Aerobic pre conditioning can help with hypertrophy1:08:30. Anabolic resistance and aging1:12:25. Connective tissue and training responses with aging1:15:20. Satellite cells and muscle growth1:17:45. Takeaway messages1:19:01. Outro Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: [email protected] to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice