Anansi saves the world, or he does not. The world ends, or it does not.

Anansi and his crew attempt to take out Pritchard and Daucina, but are surprised by Iktomi and Coyote, who lead them to the Neutrino Detector, a giant ball suspended 30 feet in the air, filled with radioactive water. Under Loki's orders, Coyote straps Anansi to the outer shell, but with a wink and a smile, he neglects to actually fasten the straps.

Using his powers, and a demonstration of his rather unique abilities, Anansi manages to convince the employees of the Sudbury Neutrino observatory that they need to help him if they want to live. Preparing them as best he can, he takes the elevator back to the surface, where the other gods await. They return, to face the ramshackle saviours of humanity.

Loki, Anansi, Coyote and the rest of the gods travel to the Sudbury Neutrino Observatory to begin the end of the world. Fuelled by Loki's cruel taunts, Anansi promises him that he will not make it through the night alive. Loki laughs off this threat, and instructs Anansi to get down to the bottom of the mine shaft, overcome any resistance, and send the elevator back up. Changing into a cave spider, Anansi travels down and down and down, Loki's evil words his only companions as he descends...

The gods meet once again, and Loki outlines his plan to them. They will go to the Sudbury Neutrino Observatory, where they will have access to thousands of litres of heavy water, that is to say, nuclear material. Anansi is at first sceptical, but Loki assures him that his plan, a combination of both magic and science, will work.

Coyote and Anansi try to have a civilized dinner, but Kanene realizes that something is amiss and drugs Coyote. Anansi uses the Baron’s hat and bones to transport them to the library, where they warn Judy. Thinking his friends are safe, Anansi is ambushed by Pritchard.

Anansi, Coyote and Kanene attempt to enjoy a nice dinner, perhaps their last on earth as we know it. Kanene shows that she is more then she seems, and incapacitates Coyote. They rush to the library and attempt to warn Judy, but are interrupted by Pritchard.

Anansi and Coyote take the final step in their con, but are interrupted by the man in black, who reveals his true nature to them. Coyote makes a shocking decision, one that changes the nature of the partnership completely.

"Anansi is kidnapped by Baron Samedi, who takes him to the crossroads and shows him two possible futures for Kanene; her dying a horrible death at a young age, or living a long and peaceful life. Anansi has a choice to make - join Iktomi, or lose Kanene forever.

Coyote and Anansi escape from the police station, and manage not to kill anyone, but just barely. Coyote suffers from a crisis of confidence, but is brought around with words of encouragement from Anansi. The partners uncover unsettling information about both Judy and Prichard, and Anansi is visited by his nameless attacker.

Anansi has a rude awakening when he discovers that his break and enter at the bank was captured on film, and his naked form is now splashed all over the news. The partners head off to return Judy's books, but she becomes defensive when they question her about the amazing and slightly impossible details she included in her notes. Coyote goes to the police station to deal with his infraction, but doesn't come out. Anansi mounts a one man rescue, but he meets a cop who is more than he seems.

Anansi goes to great lengths to correct a terrible mistake, and almost pays the ultimate price. Coyote has a run in with the police, and the partners discuss how their plans are going awry over coffee.

Anansi, posing as a moneyed heir, meets the manager of the bank. Thinkgs are going swimmingly, until the manager is called away by the sudden arrival of several very angry customers who think that their accounts have been compromised. Anansi sets up the next step of the con, and he and Coyote try to relax with an afternoon of scamming on the streets again.

Anansi and Coyote collect the overwhelming amounts of research material that Judy has prepared for them. With it, they are able to identify their attackers as tricksters and gods from a variety of cultures. Although confused as to why they have suddenly been targeted, the partners attempt to focus their energies back to the long con they are trying to run. After all, the bank is not going to just give them its money, now is it?

Anansi, after accidentally killing the fairy king , finds himself ambushed by a group of the king's loyal subjects. He uses every trick up his sleeve, but is badly outnumbered and near death. Coyote lets it slip to Judy that he and Anansi are, in actual fact, immortal gods, something that Anansi had been trying to keep on the down low. Judy, at first terrified of them, agrees to help them, as long as they don't attempt to sacrifice her or anything like that.

Anansi and Coyote go their separate ways, Iktomi's threat still ringing in their ears. After a dull day making telephone calls to keep their con rolling, Anansi is attacked by a dozen vicious, evil fairies, furious with him for killing their king the night before. Anansi uses every trick he can, manifesting himself as a variety of different spiders in order to trap, poison and rend the fairies limb from limb. But can he outwit them all?

Anansi and Coyote have an amazing night at the Hold Steady concert, and Coyote shares information about Iktomi, including the fact that he is, for lack of a better word, a total loser. However, after the show they discover he is a loser with impressive friends when he accosts them in a parking garage, accompanied by some powerful trickster gods.

Coyote decides to take Anansi to a concert, and Anansi takes Coyote home for dinner as thanks. Coyote easily charms Kanene, and more is revealed about his past, including the fact that a pemmican curry is not at good as you might think. The partners head off into the night, and Anansi makes reference to difficult, and perhaps deadly, times ahead.

Kweku does some research on his new friend and partner Michael. He discovers that Michael is much more than he bargained for. He also discovers the identity of his attacker, and the possible connection between his new friend and foe.

Kweku and Michel hatch a scheme to con the biggest mark of all: the Canadian Imperial Bank and Empire. At first nervous about the high visibility of a scam that has them dressing like security guards and mechanics, collecting information from people at bank machines, they eventually settle into a comfortable rhythm, until Kweku is blindsided by an attacker who appears to be, like him, as much spider as man.

In this episode of Lost Gods, disaffected trickster Kweku Anansi gets interrupted in the middle of a short con by a mysterious Indian, who schools Anansi in, among other things, the politically correct name for his people (First Nations), the fact that Kweku is far too nice a person to be very threatening, and running a technologically savvy scam can net a thousand dollars a pop.