Jupiter’s moon Io has likely been volcanically active since the start of the Solar System, and a proposal to safeguard healthy human subjects in clinical trials First on the show this week, a look at proposed protections for healthy human subjects, particularly in phase 1 clinical trials. Deputy News Editor Martin Enserink joins host Sarah Crespi to discuss the risks healthy participants face when involved in early testing of drugs for safety and tolerance. Then, we hear about a project to establish a set of global standards initiated by the Ethics Committee of France’s national biomedical research agency, INSERM.   Next on this episode, a peek at the history of the most volcanically active body in the Solar System, Jupiter’s moon Io. Because the surface of Io is constantly being remodeled by its many volcanoes, it’s difficult to study its past by looking at craters or other landmarks. Katherine de Kleer, assistant professor of planetary science and astronomy at the California Institute of Technology, talks about using isotopic ratios in the moon’s atmosphere to estimate how long it’s been spewing matter into space.   This week’s episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Martin Enserink   Episode page: https://www.science.org/doi/10.1126/science.zyq2ig8 Learn more about your ad choices. Visit megaphone.fm/adchoices