The theme of the "Science of Abundance Daily Alchemy" podcast, hosted by Sean Clayton, revolves around personal development and self-discovery. It explores ways to 'alchemize' or transform one's life, employing a variety of tactics, methods, or 'hacks' that the host has gathered from his own experiences. Central to the discussions is the concept of the seven laws of the universe. The podcast encourages listeners to approach life's ups and downs with a mindful attitude towards their thoughts and emotions, thereby creating a positive impact in their lives.