Subscribe to our channel: https://www.youtube.com/@optispan Grief: one of the most profound emotions humanity shares; a universal experience that transcends time, culture, and place; a phenomenon as ancient as human existence. Grief is as intrinsic to the human experience as joy or hope, and no one escapes it—to grieve is to be human. In this episode, Matt and Nick discuss their recent personal experiences with grief and loss. Matt lost his German Shepherd Dobby to degenerative myelopathy,...

Subscribe to our channel: https://www.youtube.com/@optispan Related episode: People are GETTING THIS WRONG about Supplements & My Supplement List: https://www.youtube.com/watch?v=_UXk_ynCNUs In this episode, Matt sits down with naturopathic doctor and primary care provider Kim Celmer to discuss the distinct approach naturopathic doctors (NDs) bring to patient care, addressing common misconceptions about complementary and alternative treatment modalities and explaining how NDs treat...

Subscribe to our channel: https://www.youtube.com/@optispan Related episode: Defining "Healthspan" & its role in LIVING LONGER: https://www.youtube.com/watch?v=cI6CNFeBl88 Author and physician Peter Attia popularized the concept of "Medicine 3.0", the third in a series of distinct phases—Medicine 1.0 and Medicine 2.0 included—that describe the evolution of medicine as we know it. In this episode, Matt takes us through these phases and proposes a "Medicine 4.0" as the best next step...

Subscribe to our channel: https://www.youtube.com/@optispan How much longer might humans live? This question has fascinated scientists, philosophers, and dreamers for centuries. The average human lifespan has already increased dramatically over the past hundred years thanks to advances in medicine, public health, and technology, and the prospect of radically extending human life remains one of humanity’s most compelling frontiers. A recent paper published in the scientific journal Nature...

Subscribe to our channel: https://www.youtube.com/@optispan Here's another Ask Matt Anything episode, with questions from Nick for Matt about topics ranging from the nitty-gritty of bloodwork and workout schedules to bigger-picture questions about upper limits to human lifespan, issues with the US healthcare system, and incentives for food companies to prioritize healthy options. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Brain Disorder Expert: Tackling Alzheimer's & Other Brain Disorders with LITHIUM: https://www.youtube.com/watch?v=ebj-3MuAKRs Check out Woodinville Psychiatric: https://www.woodinvillepsychiatric.com/ Matt and psychiatrist Jon Berner discussed the potential of rapamycin and ketamine for treating severe depression and chronic pain, focusing on their impact on microglia and brain inflammation. They touch on...

Subscribe to our channel: https://www.youtube.com/@optispan Check out the New York Times article: https://www.nytimes.com/2024/09/24/well/live/rapamycin-aging-longevity-benefits-risks.html Related episodes: “Zombie” Senescent cells may play HUGE role in LIVING LONGER, Here's How: https://www.youtube.com/watch?v=-H6cDIl6pgo NEW PEARL Trial Results: Your Questions Answered on Aging with Rapamycin for Longevity: https://www.youtube.com/watch?v=JUAXqSSnXzo Matt and Nick discuss a recent New...

Subscribe to our channel: https://www.youtube.com/@optispan Check out the study on caffeine and cortisol secretion: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2257922/?__hstc=3584879.1bb630f9cde2cb5f07430159d50a3c91.1522713601929.1522713601930.1522713601931.1&__hssc=3584879.1.1522713601932&__hsfp=1773666937 Check out James Hoffman's views on delaying caffeine intake in the morning: https://www.youtube.com/watch?v=yCJr49GU9yY Coffee: one of the world's most popular beverages, a...

Subscribe to our channel: https://www.youtube.com/@optispan Check out the paper: https://www.sciencedirect.com/science/article/pii/S0092867424009140?casa_token=6qa0LtsLh8QAAAAA:Iid3EX1qav1JTfkO5Skj787iUo6bJjD4dAgjvK_2ix5JirSEakRCc92m_W0G5CgNdLZR-RT4B4Q In September 2024, the scientific journal Cell published a paper suggesting that metformin slows the pace of biological aging in male primates. Metformin is an FDA-approved prescription medication commonly used to treat type 2 diabetes by...

Subscribe to our channel: https://www.youtube.com/@optispan We recently came across a study published in the European Journal of Nutrition that examined the relationship between plant and animal protein intake and measures of biological aging. The study, which uses data from the UK Biobank, a long-term database of biological data from half a million participants in the United Kingdom, found that a higher plant protein intake correlates inversely with biological aging. Matt takes us through...

Subscribe to our channel: https://www.youtube.com/@optispan More about the Dog Aging Project: https://dogagingproject.org/ The Dog Aging Institute: https://dogaginginstitute.org Enroll your dog in the Dog Aging Project: https://redcap.dogagingproject.org/surveys/?s=DYYDHK8HAP We get lots of feedback and questions about the Dog Aging Project (DAP) from viewers, so we wanted to provide an update about how the project is going as well as some context. In this episode, Matt dives into the...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Current Healthcare ISN'T CUTTING IT: How Optispan is REVOLUTIONIZING it: https://www.youtube.com/watch?v=yc2kiKsm-Z0 Aging Expert Explains How Healthcare got it ALL WRONG: https://www.youtube.com/watch?v=PAEx-5CdX94 Your health doesn't need to be complicated. With so much conflicting information out there, it's easy to feel overwhelmed and unsure of what truly works. At the Optispan Podcast, we focus on cutting...

Subscribe to our channel: https://www.youtube.com/@optispan Check out the PEARL trial webinar with Dr. Z of AgelessRx, Oliver Medvedik of Genspace, and Matt Kaeberlein: https://www.youtube.com/watch?v=dEXBFlQOTf4&t=1217s Check out the preprint discussing PEARL trial results after one year: https://www.medrxiv.org/content/10.1101/2024.08.21.24312372v1 Check out the PEARL trial listing: https://clinicaltrials.gov/study/NCT04488601 The AgelessRx-sponsored Participatory Evaluation of...

Subscribe to our channel: https://www.youtube.com/@optispan Check out the paper: https://www.nature.com/articles/s41586-024-07701-9.pdf Related episodes: The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY A recent paper demonstrating that injecting older mice with an anti-IL-11 drug extended their median lifespan made a splash in the geroscience community this summer. IL-11 is a proinflammatory cytokine that plays a role in...

Subscribe to our channel: https://www.youtube.com/@optispan Check out paper #1 on IL-11 signaling: https://www.nature.com/articles/s41586-024-07701-9.pdf Check out paper #2 on combination trametinib/rapamycin treatment: https://www.biorxiv.org/content/biorxiv/early/2024/07/25/2024.07.25.605097.full.pdf Related episodes: An introduction to the study of RAPAMYCIN: https://www.youtube.com/watch?v=czx_-DqnnrQ&t=1s In this episode, Matt discusses two recent mouse lifespan studies: one...

Subscribe to our channel: https://www.youtube.com/@optispan Check out Scott Carney's channel: https://www.youtube.com/@sgcarney Related episodes: The True Story of David Sinclair's Longevity Lie: https://www.youtube.com/watch?v=xQrXs7CxIjk DON'T Take Resveratrol Until You Watch This Video: https://youtu.be/MmIBdqsQYfw Scientists Debate How to Live Longer & Longevity Drugs: https://youtu.be/EebH_taOlAA An introduction to the study of RAPAMYCIN: https://youtu.be/czx_-DqnnrQ In this...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Scientists Debate How to Live Longer & Longevity Drugs: https://youtu.be/EebH_taOlAA Supplement Industry Secrets: What They Aren't Telling You About NAD+ & NMN" https://youtu.be/OgsfIUfuyqk NAD+ boosters are supplements designed to enhance levels of nicotinamide adenine dinucleotide (NAD+), a central coenzyme found in all living cells and involved in innumerable biochemical reactions that include DNA...

Subscribe to our channel: https://www.youtube.com/@optispan Check out Productive Health: https://productivehealth.org/ Check out the Garrison Lab: https://garrisonlab.com/ We had a great time hosting Dr. Jennifer Garrison from the Buck Institute for Research on Aging to talk about her areas of expertise: reproductive aging and neuropeptide signaling. Jennifer and Matt go over the fascinating and chronically under-researched science of menopause, misconceptions about hormone replacement...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Scientists Discuss Longevity Interventions & Optimisms: https://youtu.be/Itx1FvJfDXc This summer, Matt and Nick visited MYOXCIENCE Nutrition founder and content creator Mike Mutzel at his home to give saunas and cold plunges a try. In this episode, they share their personal experiences with both, noting the mental and physical effects they experienced during and afterward, and emphasize the importance of...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Comparing Bryan Johnson's RAPAMYCIN DATA: INTERESTING RESULTS: https://youtu.be/1-ZKzfQDQYk Why Drinking a Banana Smoothie IS the Same as Eating a Banana: https://youtu.be/Dg7S33-75_E Supplement Industry Secrets: What They Aren't Telling You About NAD+ & NMN: https://youtu.be/OgsfIUfuyqk Scientists Discuss Longevity Interventions & Optimisms: https://youtu.be/Itx1FvJfDXc Scientists Debate How to Live...

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Why DEXA Scans Are NOT the HOLY GRAIL of BODYFAT Testing - Science Explained: https://www.youtube.com/watch?v=2Gg4Jm5KS1Y Are DEXA scans ACCURATE? What YOU NEED to KNOW: https://youtu.be/SsDJZMlM1ko The UNEXPECTED Ozempic Weight Loss Body Scan Results (DEXA): https://youtu.be/C_Z7qPVRA5M Coach, bodybuilder, and powerlifter Greg Doucette published a video on his Youtube channel discussing what he sees as the...