What is vasopressin and how is it connected to Polycystic Kidney Disease? In this episode, the PKD Dietitian is going to: Break down exactly what vasopressin is. Explain how it functions in the body and how it affects your kidneys. Highlight how it impacts PKD cyst growth. PLUS share dietary and lifestyle factors that impact vasopressin levels...for better or worse.   RESOURCES BLOG: What is a Good Fluid Goal for Polycystic Kidney Disease? EPISODE 3:  Listener Q - How Much Water Should I Drink?   REFERENCES Torres VE. Salt, water, and vasopressin in polycystic kidney disease. Kidney Int. 2020;98(4):831-834. doi:10.1016/j.kint.2020.06.001 ARTICLE LINK Van Gastel MDA, Torres VE. Polycystic Kidney Disease and the Vasopressin Pathway. Ann Nutr Metab. 2017;70 Suppl 1:43-50. doi:10.1159/000463063 ARTICLE LINK Taylor JM, Hamilton-Reeves JM, Sullivan DK, et al. Diet and polycystic kidney disease: A pilot intervention study. Clin Nutr. 2017;36(2):458-466. doi:10.1016/j.clnu.2016.01.003 ARTICLE LINK Amro OW, Paulus JK, Noubary F, Perrone RD. Low-Osmolar Diet and Adjusted Water Intake for Vasopressin Reduction in Autosomal Dominant Polycystic Kidney Disease: A Pilot Randomized Controlled Trial. Am J Kidney Dis. 2016;68(6):882-891. doi:10.1053/j.ajkd.2016.07.023 ARTICLE LINK Maatje D.A. van Gastel, Vicente E. Torres; Polycystic Kidney Disease and the Vasopressin Pathway. Ann Nutr Metab 15 June 2017; 70 (Suppl. 1): 43–50. ARTICLE LINK Torres, Vicente E.; Harris, Peter C. Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease. Journal of the American Society of Nephrology 25(1):p 18-32, January 2014. | DOI: 10.1681/ASN.2013040398 ARTICLE LINK Wang, Xiaofang; Wu, Yanhong; Ward, Christopher J.; Harris, Peter C.; Torres, Vicente E.. Vasopressin Directly Regulates Cyst Growth in Polycystic Kidney Disease. Journal of the American Society of Nephrology 19(1):p 102-108, January 2008. | DOI: 10.1681/ASN.2007060688 ARTICLE LINK Tasneem M, Mannix C, Wong A, Zhang J, Rangan G. Is serum copeptin a modifiable biomarker in autosomal dominant polycystic kidney disease?. World J Nephrol. 2018;7(2):51-57. doi:10.5527/wjn.v7.i2.51 ARTICLE LINK Bankir L, Roussel R, Bouby N. Protein- and diabetes-induced glomerular hyperfiltration: role of glucagon, vasopressin, and urea. Am J Physiol Renal Physiol. 2015;309(1):F2-F23. doi:10.1152/ajprenal.00614.2014 ARTICLE LINK Alwis US, Delanghe J, Dossche L, et al. Could Evening Dietary Protein Intake Play a Role in Nocturnal Polyuria?. J Clin Med. 2020;9(8):2532. Published 2020 Aug 5. doi:10.3390/jcm9082532 ARTICLE LINK Grantham, Jared J.. Therapy for Polycystic Kidney Disease? It's Water, Stupid!. Journal of the American Society of Nephrology 19(1):p 1-7, January 2008. | DOI: 10.1681/ASN.2007101100 ARTICLE LINK Yamada Y, Fujiki H, Mizuguchi H, et al. Nihon Yakurigaku Zasshi. 2022;157(4):254-260. doi:10.1254/fpj.22006 ARTICLE LINK Rangan GK, Wong ATY, Munt A, et al. Prescribed Water Intake in Autosomal Dominant Polycystic Kidney Disease. NEJM Evid. 2022;1(1):EVIDoa2100021. doi:10.1056/EVIDoa2100021 ARTICLE LINK Sparapani S, Millet-Boureima C, Oliver J, et al. The Biology of Vasopressin. Biomedicines. 2021;9(1):89. Published 2021 Jan 18. doi:10.3390/biomedicines9010089 ARTICLE LINK   DISCLAIMER The PKD Dietitian Podcast is meant for educational purposes only.  Information presented should not be used in place of advice from a medical professional.