Meet Todd Georgieff - a veteran in drug development and clinical operations with expertise in optimizing global trials. In this episode, Todd and Maya explore the critical aspects of protocol optimization and patient burden quantification. How does understanding local standard of care impact trial success? What are the ethical implications of providing treatments in different healthcare systems? Todd shares insights on these questions and more. Follow Maya Zlatanova: https://www.linkedin.com/in/mayazlatanova/Follow Todd Georgieff: https://www.linkedin.com/in/toddgeorgieff/ (00:00) - Introduction and Background (03:12) - Understanding the Local Patient Pathway and Standard of Care (10:54) - Making Clinical Trials More Attractive to Patients (19:29) - The Implications of Not Considering Standard of Care (23:37) - Quantifying Patient Burden in Clinical Trials (28:38) - Feasibility of Quantification Method for Global Trials (37:47) - The Future of Clinical Trials: Data Interoperability (41:41) - Predicting the Next Game Changer for Clinical Trials