Part 2 of the fascinating discussion with Dr. Francisco Gonzalez-Lima on Cytochrome Oxidase and Methylene Blue. Part 1 was an introduction to Cytochrome Oxidase and the history of methylene blue. Part 2 is a deep dive into the benefits and current science behind Methylene Blue. Who is Dr. Francisco Gonzalez-Lima?  Francisco Gonzalez-Lima, Ph.D., is a courtesy professor in the Department of Psychiatry. He also holds the George I. Sanchez Centennial Professorship at The University of Texas at Austin, where he is a professor in the departments of Psychology, Psychiatry, Pharmacology and Toxicology and the Institute for Neuroscience. Gonzalez-Lima’s teaching experience includes undergraduate, medical, graduate and postdoctoral students, and he currently teaches the core graduate course in Functional Neuroanatomy. Gonzalez-Lima has been the research adviser of 22 Ph.D. students at UT Austin, and his trainees are world leaders in brain research on the relationship between brain energy metabolism, memory and neurobehavioral disorders. Gonzalez-Lima graduated with honors from Tulane University in New Orleans with a Bachelor of Science in biology and Bachelor of Arts in psychology, and he earned his doctorate in anatomy and neurobiology from the University of Puerto Rico School of Medicine, which honored him with a Distinguished Alumnus Award. He completed postdoctoral training (behavioral neuroscience) at the Technical University of Darmstadt, Germany, as an Alexander von Humboldt research fellow. Gonzalez-Lima has been a visiting neuroscientist in Germany, England, Canada and Spain and he has delivered more than 120 invited lectures about his brain research around the world. His research has been funded for more than 30 years with federal and private funds, and he has contributed to more than 350 scientific publications in peer-reviewed journals, conference proceedings, chapters and books. Current research in the Gonzalez-Lima laboratory focuses on the beneficial neurocognitive and emotional effects of noninvasive human brain stimulation in healthy, aging and mentally ill populations. This research primarily uses transcranial infrared laser stimulation and multimodal imaging (EEG, fNIRS and fMRI) in collaboration with colleagues at UT Austin, The University of Texas at Arlington and University of Texas Southwestern Medical Center. Gonzalez-Lima supervises and trains students and residents to contribute to these ongoing brain research projects. Highlights [3:45] Methylene Blue's Dose Dependent Curve [10:25] Poison Control [18:00] Focus, Alzheimer's, and Protecting Against Cognitive Decline [24:35] Why Pharmaceutical Grade Matters [31:28] Leucomethylene Blue and Skin Care [46:10] Concerns over long term use of Methylene Blue Resources Methylene Blue Preserves Cytochrome Oxidase Activity and Prevents Neurodegeneration and Memory Impairment in Rats With Chronic Cerebral Hypoperfusion Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration Hormetic Dose Response Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease by Dr. Francisco Gonzalez-Lima Alzheimer’s Turning Point by Jack De La Torre Sponsors Troscriptions  One of my favorite tools for cognitive enhancement, especially after long plan rides, is Blue Cannatine. The delivery mechanism is unique (buccle troche). It is especially effective for me on improving short-term memory, focus, and verbal fluency. It’s the closest thing that I found to NZT and I think you guys should try it out. Get yours at troscriptions.com. Full disclosure: I am involved with the company (I like the product that much). Vielight Vielight combines science and engineering ingenuity to develop unique devices that deliver photons to the brain and inner systems. Their mission is to create photobio