In the last decade, Russia has increased its global engagement, while at the same time pursuing policies at home that are giving rise to HIV/AIDS and drug-resistant tuberculosis epidemics that are a risk for its own populations, as well as its neighbors. These developments have unfolded against a backdrop of highly malevolent Russian behavior across many fronts that has resulted in the imposition of extensive sanctions. In this special joint episode of Take as Directed and Russian Roulette, J. Stephen Morrison sits down with Jeff Mankoff, Acting Director of the CSIS Russia and Eurasia Program; and Judyth Twigg, Professor of Political Science at Virginia Commonwealth University and a Senior Associate with the CSIS Russia and Eurasia Program. The three discuss their recent analysis, “Putin and Global Health: Friend or Foe?” which outlines an opportunity to expand U.S. engagement to promote health security and counter Russian influence in Eastern Europe and Central Asia.