In this episode of "Office Hours Live," Dr. Eric Trexler and Dr. Eric Helms discuss the newest issue of the MASS Research Review, focusing on Helms' article about muscle reallocation in untrained individuals. They discuss a study examining muscle volume changes during resistance training, exploring its methodology, findings, and implications for body recomposition and protein/energy intake. The conversation covers practical applications for bodybuilders and athletes, before transitioning into a Q&A session addressing topics such as supplement tiers, general health supplements, and the use of multivitamins. The hosts explain the importance of third-party testing for supplements and discuss isometric training, including its potential benefits and current research gaps. The episode also features rapid-fire questions on protein intake and longevity, exercise selection, underrated muscles for aesthetics, quad development strategies, and long-term creatine use. Throughout the discussion, Trexler and Helms provide in-depth analysis of scientific studies while offering personal insights and practical advice for listeners. The MASS crew goes live for Office Hours every Wednesday night at 7pm eastern time. Be sure to join us for a future episode! If you'd like to submit a question ahead of time, please use this link: https://massresearchreview.com/office-hours/ Time stamps: 0:00 Intro and discussion of the latest MASS Research Review issue, focusing on Dr. Helms' article about muscle reallocation in untrained individuals 9:17 Detailed explanation of the study on muscle volume changes during resistance training, including methodology and findings 20:52 Implications of the study and its relation to body recomposition and protein/energy intake 29:42 Discussion on the practical applications of the study findings for bodybuilders and athletes 38:05 Q&A session begins, covering topics such as getting less of a "burn" from familiar exercises over time and supplements for general health supplements 46:08 Discussion on isometric training, its potential benefits, and current research gaps 1:03:13 Debate on the use of multivitamins and the importance of third-party testing for supplements 1:24:15 Rapid-fire questions covering topics like protein intake and longevity, comment section interactions, and exercise selection 1:31:02 Discussion on underrated muscles for aesthetics and quad development strategies 1:36:48 Final questions on long-term creatine use and closing remarks