I am thrilled to have Dr. Nick Norwitz, a researcher-educator on a mission to mainstream metabolic health, joining me today. Dr. Norwitz is a Dartmouth College graduate who completed his Ph.D in metabolism at Oxford University before attending Harvard Medical School to complete his MD.  Dr. Norwitz is passionate about teaching and encourages everyone to join the growing camp of metabolic health enthusiasts who will be instrumental in changing the world. In today's conversation, we explore the complex and controversial world of non-nutritive sweeteners, covering several topics, including the effects of allulose on PCOS, metabolic medicine, and the research on how gut sensor cells impact our preference for sugar over sweeteners. We look into studies on sucralose, commonly known as Splenda, and Dr. Norwitz shares insights from his Oreo LDL reduction experiment. We also touch on our human tendency toward simplicity and confirmation bias, the importance of bio-individuality, and the concept of N=1 medicine. Dr. Norwitz is committed to remaining curious. He will return to the podcast later this year to share more about the research on metabolic health, muscle, and metabolism. I know you will love this discussion, so stay tuned for more. IN THIS EPISODE YOU WILL LEARN: How the different molecules that exist within various types of non-nutritive sweeteners impact our biology Dr. Norwitz explains how his view on non-nutritive sweeteners has shifted over time. Why is allulose such a unique non-nutritive sweetener? How the brain can distinguish between different sweetener molecules, and why that can drive changes in behavior   Dr. Norwitz explains how the hypothesis that sucralose may cause insulin resistance, was proven incorrect. Why some non-nutritive sweeteners may be more problematic than others Dr. Norwitz shares his approach to creating engaging social media content and discusses his famous Oreo versus statin experiments. Why Dr. Norwitz believes that there should be more studies on lean mass hyper-responders How dietary changes affect LDL cholesterol levels What is N=1 medicine? Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Nick Norwitz X/Twitter YouTube Instagram LinkedIn Threads FaceBook Weekly Newsletter