In this video, Douglas Lucas discusses the complexities of hormone replacement therapy (HRT) for women with osteoporosis, particularly in the context of family history of breast cancer. He emphasizes the importance of understanding the risk-benefit equation when considering estrogen therapy, especially for women who may have a significant family history of breast cancer. Through various studies, he highlights how family history impacts breast cancer risk and the nuances involved in making informed health decisions regarding hormone therapy. Study Links: https://pubmed.ncbi.nlm.nih.gov/36262035/ https://pubmed.ncbi.nlm.nih.gov/28986348/ https://pubmed.ncbi.nlm.nih.gov/19904271/ https://pubmed.ncbi.nlm.nih.gov/11705483/