We've all seen headlines about Ozempic, Wegovy, Mounjaro and Zepbound. These GLP-1 Agonist injections have become the most popular new pharmaceutical in decades. They have tremendous potential to radically change the lives of millions of people, but they aren't without their risks.  For the next two episodes, the boys are taking a closer look at what these drugs do and how they do it. To do that, we've got to have a clear idea of the problems they're looking to address: Type 2 Diabetes and Obesity as a disease state. ALL PRODUCTS: https://www.AskJoeDimatteo.com CONNECT: Products - https://askjoedimatteo.com/youtube Questions - [email protected] Facebook - https://facebooke.com/askjoedimatteo Instagram - https://tinyurl.com/5n6kfwhs PODCAST: Apple Podcasts - https://tinyurl.com/GHShowApple Google Podcasts - https://tinyurl.com/GHShowGoogle Spotify - https://tinyurl.com/GHShowSpotify Rumble - https://rumble.com/user/GenerationHealth YouTube - https://tinyurl.com/57hxe6aj YouTube Clips - https://tinyurl.com/wzk69tbk Generation Health is a weekly podcast discussing cutting edge research and time tested best practices to help you live better, longer. Dante DiMatteo (PharmD, CSCS) is the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating his extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, he loves sharing his wisdom with anyone looking to improve their life! CHAPTERS: 00:21 - Show Intro 03:12 - What is digestion? 06:04 - How does insulin work? 07:41 - Other hormones that aid in digestion 11:10 - What is GLP-1? 15:07 - Diabetes Basics 16:51 - How does obesity factor in? 18:25 - Additional points on GLP-1 21:18 - Obesity as a disease state 29:58 - What are GLP-1Agonists? 36:22 - GLP-1 + GIP Agonists 40:04 - Who are good candidates for these drugs? 42:29 - BMI as a tool 45:05 - How effective are these drugs? 51:05 - What are the downsides? 55:46 - Show Outro   SHOW NOTES: 1) Digestion (NIH) - http://tinyurl.com/2fspkea8 2) Insulin (NIH) - http://tinyurl.com/4a5c8akw 3) Glucagon (NIH) - http://tinyurl.com/5bhuv7s5 4) Amylin (MDPI) - http://tinyurl.com/4wv9wkp5 5) GLP-1 (NIH) - http://tinyurl.com/vw74ktrv 6) GIP (NIH) - http://tinyurl.com/2u9xp4m7 7) OZEMPIC (semaglutide) (package insert) - http://tinyurl.com/bdzbtvk9 8) Obesity (eClinicalMedicine) - http://tinyurl.com/hd5yr3jy 9) Obesity (NIH) - http://tinyurl.com/bdhbtn8v 10) Obesity (MDPI) - http://tinyurl.com/2e24nktb DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.