We’re very excited this week on Pulm PEEPs to be resuming our Roundtable series. We are joined by two outstanding critical care doctors to discuss precision medicine in the ICU, specifically ARDS phenotypes. This is a topic of increasing clinical and research interest, and personalized medicine in the ICU will certainly change the landscape of how care is delivered in the coming years and decades. We are honing in on ARDS today and how phenotyping can influence future research and clinical care. Meet Our Guests Carolyn Calfee is a Professor of Medicine and Anesthesia at the University of California, San Francisco. She is a leader in the field of ARDS research and a pioneer in the field of ARDS phenotyping research. She has received numerous NIH grants and has literally 100s of publications on ARDS and other topics. She is also a previous ATS CC Assembly chair, and in 2022 received the ATS Recognition Award for Scientific Accomplishments. Annette Esper is an Associate Professor of Medicine at Emory University School of Medicine. She works clinically in critical care and is the Medical Director of the stepdown Intensive Care Unit at Grady Memorial Hospital. In addition to her clinical activities, Annette does both clinical and translational research in ARDS, and was the Assembly Chair for the ATS Critical Care Assembly from 2021 – 2022. Key Learning Points Berlin Criteria of ARDS: — Acute symptoms developing within 7 days of a known insult — Bilateral airspace opacites on chest imaging — Hypoxemia not fully explained by cardiogenic pulmonary edema — P:F ratio Prognostication > Identify who will be responsive to specific therapies > May not be one biomarker, will likely be a panel — What is the perfect ARDS biomarker? > Specific: identify a group of patients that are at risk, or respond to therapies differently > Easily measurable at the bedside > Reliable