Chemical Analysis is facing nowadays rapidly changing requirements on performance. Resolution of sample components over a very wide range of concentration, analysis time, selectivity and specificity are expected to improve continuously. At the same time acquisition of samples for analysis is getting more difficult since samples are much smaller and must remain representative for a chemical, biological or environmental system in time and space. In addition, analysis methods must remain affordable, easy to use, and robust and applied by professional staffs, who are not trained lab technicians. These requirements and challenges can only be met by advances of the measurement technology itself. The vision of integrating largely manual steps in chemical analysis workflow from sample handling to data analysis in one device has lead to a rigorous reduction in scale (miniaturization) and to the concept of "Lab-on-a-Chip".