In this episode of a16z Live, Chris Power, the Founder and CEO of the precision parts manufacturing company, Hadrian, talks with a16z American Dynamism Partner Oliver Hsu, about why he decided to build his factories in LA, why software engineers shouldn't be afraid of manufacturing company jobs, and how a single mom and pop machinist shop can affect the national supply chain. What follows is a slightly edited version of that conversation.

To celebrate the L.A. community and the city's growth, a16z recently hosted, "Time to Build Los Angeles," an event where we invited L.A.-based investors, founders, and operators from across a diverse range of industries to talk about company building in L.A. In the first in our series of interviews, we invited Andrew Chen from a16z, Minnie Ingersoll from TenOneTen, and Turner Novak from Banana Capital to talk about why L.A. is at an inflection point, misperceptions about the region, and what...

In this episode of a16z Live, we are joined by Titan Invest co-founder and co-CEO Clayton Gardner; a16z General Partner Anish Acharya; and a16z growth partner, Alex Immerman. The trio starts their conversation by diving into the difference between active and passive investment management and where Titan fits into that matrix. Building upon that foundation, they discuss how the fintech market is changing, why historically the best fund managers have not taken retail money, and whether that's...

Ben Horowitz discusses the leadership styles of Intel’s Andy Grove and Apple’s Bill Campbell, how Okta won its market with culture, and how to look for and hire the talent you don’t have in an interview with David Weiden, founding partner at Khosla Ventures, at the Khosla Ventures CEO Summit.

The API economy and a Cambrian explosion of apps are transforming best-in-class tech from monolithic tools to a stack of 20 applications that work together. Amid this unbundling, partnerships have become a critical part of early go-to-market strategy that can lead to higher quality pipeline and accelerated sales. In this fireside chat, recorded at the 2022 Crossbeam Supernode conference, a16z General Partner Sarah Wang and Bob Moore, Cofounder and CEO of Crossbeam, discuss how partnerships...

a16z General Partner David Haber chats with his former colleague Stephanie Cohen, Goldman Sachs' Global Co-Head of Consumer and Wealth Management, about her journey from being an investment banker to running a global division, how Goldman Sachs stays relevant to different client audiences, and how fintech entrepreneurs can think about partnering with the financial services giant.

As the deputy director for the Cybersecurity and Infrastructure Security Agency (CISA), Nitin Natarajan spends most of his days worrying about everything from risk identification and mitigation, to educating young people and small businesses on their potential to be victims. In this fireside chat with Joel de la Garza, a16z operating partner for security, the two men discuss what keeps the CISA official up at night, his view of the situation in Ukraine and Russia, and how being tech savvy...

Katherine Boyle, General Partner at a16z is joined by Hadrian founder and CEO Chris Power, Packy McCormick, founder of Not Boring, and a16z co-founder Marc Andreessen to discuss the opportunity to automate and upskill in the precision parts industry and shore up U.S. manufacturing with new technology.

An excerpt from a Clubhouse conversation, where Marc interviews Ken Griffin, CEO and founder of Citadel, on GameStop one year later and why the stock price hasn't crashed, as well as about his winning bid for the Constitution in the auction against ConstitutionDAO.

As our healthcare system has adopted more digital tools, our electronic medical records (EMR) have become a repository of real world patient data -- that is, patient data generated outside of a clinical trial. But that real world data is complex and messy, so what are the actual use cases for it? Can it be used for real-time clinical decision support, or is its utility limited to less time-sensitive use cases? a16z Bio General Partner and practicing physician Vineeta Agarwala talks to data...

Digital health companies are finding new paths to market. In this special edition of the a16z bio show, recorded live at the HLTH conference in Boston, we talk to digital health builders from Maven, Butterfly, and Bold about one of these new go-to-market (GTM) motions: B2C2B, or bottom up, that starts direct to consumer before selling to businesses and organizations. Why did they choose this motion? What makes it so powerful? And what tips do they have for other founders?

Marc and Ben on why the efficient market hypothesis isn't quite what it seems, stocks don't really exist, and all information is by definition surprise.

Indra Nooyi is the former chairperson and CEO of PepsiCO, a current board member of Amazon, and consistently named one of the most 100 influential women in the world. In short, she's had quite the career, and in this Good Time Show, she shares her favorite management hack, why she chose PepsiCo over GE, how she handled the loneliness of leadership, and what Steve Jobs taught her about design.

How often does it happen that less than 10 people in the world know something? Is expertise knowing what others don't? Or is it a willingness to see what everyone knows in a different light?

Lyft began with a vision to reimagine cities, driving virality with pink mustaches and fist bumps. A decade later, they've weathered one of the fiercest battles for market share as well as a pandemic that tanked first rider demand and then driver supply. Cofounder and President John Zimmer as well as a16z's Ben Horowitz, who was on Lyft's board of directors for a time, talk about what it took to survive, as well as where they see the future of transportation and cities.

Nearly one in seven Americans has diabetes, but our understanding of the disease has long been limited to two types (Type 1 and Type 2) with a focus on glucose and insulin. But breakthroughs in insulin delivery, glucose monitoring, stem cell therapies, and other diabetes treatments are helping to debunk misconceptions of diabetes as a lifestyle disease and evolving the ways we fight it. So, what is the current landscape of treatments? And what more will it take to cure diabetes? The a16z Bio...

Parag Mallick, Founder and Chief Scientist, at Nautilus started the company because he believed he had a game-changing innovation for how to approach proteomics (i.e., the study of proteins) with the potential to transform drug development. He talks about how he made the breakthrough, how he turned a technological advance into a product and then a company at-scale,the differences between innovating in a lab and a startup, and what's next in proteomics.

In this segment from One on One with A and Z, Marc and Ben discuss what social lessons they've learned from sitting on boards, the importance of system design in creating culture, how to address broken systems, and the classic Machiavellian question of whether it's better to lead with love or fear.

Morgan Stanley Capital International (MSCI) manages the world index, tracking more than 20,000 companies in developed, emerging, and frontier economies, and is critical to benchmarking investment opportunity as well as risk and portfolio performance. In this Clubhouse conversation, MSCI CEO Henry Fernandez talks with Alex Rampell and Scott Kupor about how MSCI got started, how they construct an index and keep it accurate, the business model around indices, and the renewed importance of ESG in...

Good Time Show on building the metaverse, and the role of crypto -- with @aarthir @3LAU @donnie @gabusch @jarroddicker @jessewldn @packyM @sriramk @Tocelot @twobadour

For many SaaS companies, the cost of cloud can be 50% or more of COGS. When does the cost of cloud become too much? a16z Infra host Martin Casado brings together guests with different strategies and experiences for managing the cost of cloud, from full repatriation to doubling down on AWS.

a16z has invested in crypto since 2013, and recently, we announced a $2.2B Crypto Fund III. In this episode of the Good Time Show, the a16z Crypto team talks crypto and crypto investing -- where it is now, how it got here, what it needs to tackle next, and why we continue to believe it is "part two of the internet."

Creating a new category is often seen as the holy grail for startups. But can you actually create a category? And if so, how do you do it? When to launch, branding, pricing and packaging, and more with category makers.

Consumer habits in China, social shopping, influencers and communities, breaking the brand to make the brand, ... and what innovation in retail means for what and how we consume. The a16z Consumer team talks with leaders from Shopify, Modern Citizen, and Verishop.

Growth hacking is one of the biggest buzz words among startup founders and marketers. We debate what it is (and isn't), as well as is (and isn't) effective, with three long-time growth hackers: Morgan Brown (VP of Growth, Shopify), Fareed Mosavat (VP Programs & Partners, Reforge), and a16z general partner Andrew Chen.