When Dr. Ashley Walker (University of Oregon) began to study sex differences with vascular aging and cognitive decline, she and her team went to the literature for guidance on research study design to account for the confounding variable of estrous cycle in young female mice. Problem: There were no recommendations in the literature. Solution: The Walker Lab got to work. In our latest episode, Dr. Amanda LeBlanc (University of Louisville) interviews lead author Dr. Ashley Walker and first...

Have you ever had an experimental design deviate from expectations? Well, this episode is for you. Associate Editor Dr. Keith Brunt (Dalhousie University) interviews Deputy Editor Dr. Zamaneh Kassiri (University of Alberta) about her recently published article by Hu et al., along with content expert Dr. Joshua Man ( Tufts Medical Center), to discuss how unexpected results and negative findings can, in and of themselves, lead to new discoveries. Kassiri and co-authors used a Cre/lox system to...

Why do many severe COVID-19 survivors experience exercise intolerance as a lingering consequence of their viral infection? In this episode, Guest Editor Dr. Tiago Peçanha (Manchester Metropolitan University) interviewed lead author Dr. Hamilton Roschel (University of Sao Paulo) and expert Dr. John Durocher (Purdue University Northwest) about the latest study by Longobardi et al., which investigated the impact of previous severe COVID-19 infection on cardiorespiratory responses to a maximal...

In our latest episode of Behind the Bench from AJP-Heart and Circ, co-hosts Dr. Tommy Martin and Dr. Charlotte Usselman interview bioengineer and first author Dr. Amy Garrett. Dr. Garrett joined the Auckland Bioengineering Institute in 2016, where she completed a Masters in Engineering followed by a PhD. After joining the cardiac energetics group for her post-doc, Dr. Garrett embarked on a research journey tackling the development of the Windkessel loading system for work-loop contractions....

What is a cytokine storm in COVID-19 patients and how does it adversely affect organ systems in diabetes patients? In our latest episode, Associate Editor Dr. Keith Brunt (Dalhousie University) interviews lead author Dr. Dinender Singla (University of Central Florida) and expert Dr. Mark Chappell (Wake Forest University) about the new Review by Narasimhulu and Singla on the pathophysiology of the SARS-CoV2 virus as it relates to diabetes. As we now know, the virus enters cells through the...

How do the 3 Rs of Research – Refinement, Reduction, Replacement – factor into a methodological paper regarding a novel quantitative method for using an electrocardiogram to determine which animals have infarcts that reflect successful coronary ligation? Listen as Consulting Editor Dr. Ganesh Halade (University of South Florida) interviews lead author and Consulting Editor Dr. Kristine DeLeon-Pennell (Medical University of South Carolina) and content expert Dr. Corey Reynolds (Merck &...

Is it bad for our cardiovascular health to “spring forward” into Daylight Saving Time? On March 15, 2022, the U.S. Senate passed the Sunshine Protection Act, which aims to make Daylight Saving Time permanent and eliminate bi-annual seasonal clock changes in the spring and fall. In this episode, Consulting Editor Dr. Austin Robinson (Auburn University) interviews lead author and Associate Editor Dr. Jason Carter (Montana State University) and expert Dr. Josiane Broussard (Colorado State...

The eyes are the window to the soul, as the old saying goes, but are the eyes also the window to cardiovascular disease? Diabetic retinopathy is a common diabetic microvascular disease and a leading cause of blindness in diabetes patients worldwide. Defects in the blood-retinal barrier caused by increased production of vascular endothelial growth factor-A isoforms promote angiogenesis and permeability. Listen as Consulting Editor Dr. Shawn Bender (University of Missouri, Columbia) interviews...

This episode of Behind the Bench with AJP-Heart and Circ is full of connections. Returning co-host Dr. Charlotte Usselman is joined by her new co-host Dr. Tommy Martin. We first met Tommy when we interviewed him last year for Behind the Bench episode 10 as a trainee in the lab of AJP-Heart and Circ Associate Editor Dr. Jonathan Kirk. Jonathan was the original co-host of Behind the Bench along with Dr. Lisandra de Castro Brás. Speaking of Jonathan and Lis… big shout out to the original Behind...

First, a thank you to frontline healthcare workers, clinical researchers, and one determined master’s student Michelle Cristina-Oliveira of the Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo for their bravery and dedication to science and medicine! In this episode we bring you a conversation between Associate Editor Dr. Jason Carter (Montana State University), lead author Dr. Tiago Pecanha (Universidade de São Paulo, and Manchester Metropolitan University), and...

How does in utero glucocorticoid administration impact autonomic control of the heart in adult offspring in a sex-dependent manner? In this episode, Associate Editor Dr. Crystal Ripplinger (University of California – Davis) interviews authors Dr. Taben Hale and Lakshmi Madhavpeddi (University of Arizona) along with expert Dr. Glen Pyle (University of Guelph) about the new work by Madhavpeddi et al. The authors administered dexamethasone to pregnant rats using a dose and timing that closely...

Who knew that back in 2010, when previous Editor-in-Chief Dr. Bill Stanley said, “Podcasts! I don’t know anything about them, but I think we should do them!,” that we would still be producing The AJP-Heart and Circ Podcast 12 years and 299 episodes later?!  Since then we have talked with hundreds of authors, experts and editors around the world about the innovative and impactful research published in AJP-Heart and Circulatory Physiology. In this special anniversary episode #300, we turn the...

Are failing hearts addicted to glutamine? In this special episode of The AJP-Heart and Circ Podcast, we bring you a conversation in both Japanese and English with Editorial Board member Dr. Junichi Sadoshima (Rutgers University-New Jersey Medical School), Consulting Editor Dr. Jun Yoshioka (City University of New York School of Medicine), and corresponding author Dr. Manabu Nagao (Kobe University Graduate School of Medicine) about the new study by Yoshikawa et al. that explores the...

Are failing hearts addicted to glutamine? In this special episode of The AJP-Heart and Circ Podcast, we bring you a conversation in both Japanese and English with Editorial Board member Dr. Junichi Sadoshima (Rutgers University-New Jersey Medical School), Consulting Editor Dr. Jun Yoshioka (City University of New York School of Medicine), and corresponding author Dr. Manabu Nagao (Kobe University Graduate School of Medicine) about the new study by Yoshikawa et al. that explores the...

Impactful findings with reverberating consequences – this is what AJP-Heart and Circ Rapid Reports are here for. Listen as Associate Editor Dr. Jonathan Kirk (Loyola University Chicago Stritch School of Medicine) interviews lead author Dr. Susan Steinberg (Columbia University) and expert Dr. Michael Kapiloff (Stanford University) about this novel work by Zhu and Steinberg. More than 20 years ago, Steinberg and collaborators used immunoblot analysis to implicate compartmentalization as a...

While echocardiography is commonly used to assess cardiac structure and function in mouse models of heart disease, can this non-invasive technique also be used to accurately measure infarct size? Listen as Deputy Editor Dr. Zamaneh Kassiri (University of Alberta) interviews co-authors Dr. Erin Mulvihill (University of Ottawa) and Dr. Craig Goergen (Purdue University), along with content expert Dr. Daniele Panetta (Institute of Clinical Physiology CNR - Pisa). Dann et al. measured and...

Despite the establishment of NIH guidelines for inclusion of women in clinical studies, as well as clear expectations for rigor and reproducibility in reporting sex as a biological variable in NIH grant submissions, women and females are still understudied populations in human and animal research. Enter this important primer on incorporating sex as a biological variable into basic and clinical research. Listen as Consulting Editor Austin Robinson, PhD (Assistant Professor, Neurovascular...

Deciding on the best mouse model to research myocardial ischemic injury? Stop and listen. Associate Editor Jason Carter (Montana State University) interviewed authors Zamaneh Kassiri (University of Alberta), Crystal Ripplinger (University of California Davis), John Calvert (Emory University), Kristine DeLeon-Pennell (University of South Carolina), Dominic Del Re (Rutgers New Jersey Medical School), Richard Gumina (The Ohio State University), Steven Jones (University of Louisville), and Ganesh...

Listeners, we are bringing you a special cross-over event with The AJP-Heart and Circ Podcast. In our January 2022 episode on Cortical Bone Stem Cells Effects on Cardiac Wound Healing, we talked with senior authors Dr. Steven Houser and Dr. Timothy McKinsey about their collaboration on two recently published articles by Hobby et al. and Schena et al. In this new episode of Behind the Bench, hosts Dr. Lisandra de Castro Brás (East Carolina University) and Dr. Charlotte Usselman (McGill...

In this episode, Associate Editor Amanda LeBlanc (University of Louisville) interviews authors Lacy Alexander and Gabrielle Dillon (The Pennsylvania State University) along with content expert Melissa Witman (University of Delaware) about a new study by Dillon et al. With their lab closed due to the pandemic, the Alexander Lab continued to hold journal club meetings virtually to discuss two articles published previously in AJP-Heart and Circ – Ratchford et al. and Nandadeva et al. The...

What’s better than discussing one paper on the effects of cortical bone stem cells and their impact on myocardial infarction? Discussing two papers! Associate Editor Dr. Jonathan Kirk (Loyola University Chicago Stritch School of Medicine) interviews lead authors Dr. Timothy McKinsey (University of Colorado Anschutz Medical Campus) and Dr. Steven R. Houser (Lewis Katz School of Medicine at Temple University) along with expert Dr. Helen Collins (University of Louisville School of Medicine). The...

Permeability is an important measure of the exchange function of microvessels, but until now, there has been a lack of physiologically-relevant in vitro microvessel models that allow an easy assessment of permeability properties of the microvessel wall. In our latest episode, Associate Editor Amanda LeBlanc (University of Louisville) interviews lead author Ping He (Penn State University) and expert Robert Hester (University of Mississippi Medical Center) about the latest research study by Gao...

It is well known that exercise can have beneficial effects on brain health, including reducing the risk of dementia and stroke. Does resistance exercise training affect brain blood flow and cerebrovascular physiology differently than endurance exercise? Guest Host Brady Holmer (University of Florida) interviews first author Hannah Thomas (The University of Western Australia) and expert Timo Klein (University of Rostock) about the latest research by Thomas and co-authors which directly...

What are the goals and expectations of AJP-Heart and Circulatory Physiology over the next several years to optimize rigorous approaches to consideration of sex and gender as a biological variable in cardiovascular research? Consulting Editor Nisha Charkoudian (U.S. Army Research Institute of Environmental Medicine) interviews the entire AJP-Heart and Circ editorial team in this pivotal episode of The AJP-Heart and Circ Podcast. Listen as Editor-in-Chief Merry Lindsey (University of Nebraska...

What is the causal relationship between high-level spinal cord injury, orthostatic hypotension and increased risk for cardiovascular disease? In this episode, Consulting Editor Patrick Osei-Owusu (Case Western Reserve University) interviews authors Christopher West (University of British Columbia) and Aaron Phillips (University of Calgary), along with expert Jill Wecht (James J. Peters VA Medical Center) about the new study by Hayes et al. High-level spinal cord injury can lead to orthostatic...