KSQD 4-05-2023: Interpreting coronary artery calcium scores and how to combat coronary artery disease; Atra, a new treatment for rheumatoid arthritis has its problems; Manganese contamination in California central valley wells; Early menopause, hormone replacement therapy and Alzheimer’s disease; Cold temperatures may extend longevity by increasing breakdown of damaged, toxic proteins; Experiments with nematodes also support increased longevity in colder environments; A newly discovered interleukin involved in Crohn’s disease and ulcerative colitis can be treated by an existing drug