The AUA Expert Exchange Podcast: Discussions in Managing GU Cancer: Germline Testing in GU Cancers – How I Do It CME Available: https://auau.auanet.org/node/39544 Release Date: December, 2023 Expiration Date: December, 2024 ACKNOWLEDGEMENTS: Support provided by independent educational grants from:  AstraZeneca Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC  Lantheus Medical Imaging Merck & Co., Inc. LEARNING OBJECTIVES: At the conclusion of this activity, participants will be able to: 1. Differentiate between germline and somatic testing in the context of GU cancers, understanding the fundamental differences in the types of genetic alterations detected and their implications for patients and their families. 2. Describe the genetic counseling process and the importance of pre-test counseling to discuss the benefits, limitations, and potential implications of germline testing. 3. Evaluate the clinical significance and impact of germline testing results on treatment decisions, surveillance recommendations, and family management.