Alessio Ciulli is a Professor and Chair of Chemical Structural Biology at the University of Dundee, where he is also the founder and director of the Centre for Targeted Protein Degradation (CeTPD). He is also the scientific founder of Amphista Therapeutics. This conversation covers the significant moments in Alessio's career where he began to shape an exciting new approach in drug discovery:  targeted protein degradation. CeTPD page: https://www.dundee.ac.uk/cetpd Alessio's group page: https://www.dundee.ac.uk/people/alessio-ciulli Alessio's Twitter: https://twitter.com/alessiociulli