The effect of inappropriate blood clotting can be devastating, including heart attack and stroke. While there are many medications to reduce the risk of clotting, our understanding of why blood clots and when remains incomplete. In today’s episode of Beyond the Abstract, Derek and Dan share the remarkable story of how a team of researchers discovered new clotting biology, in a story that begins with a surprising observation about hibernating bears and ends with the characterization of a potential new drug target for humans. Thienel et al. Immobility-associated thromboprotection is conserved across mammalian species from bear to human. Science, 2023. The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.