High-yield differential diagnosis of heart sounds abnormalities including changes in the intensity and splitting of S1, S2 as well as etiologies of S3 & S4 gallops with strategies to identify them. 

Flashcard - style questions on precordial palpation and assessment of carotid and jugular (venous) pulse with discussion of important differential diagnosis of several conditions including venous wave abnormalities

Systematic questions on Radiologic anatomy and trauma assessment of cardiac box, auscultation for valvular heart disease, and ECG-correlations of coronary arteries

High-yield questions on Chronic Granulomatous Disease, Chédiak-Higashi Syndrome, Leukocyte Adhesion Deficiency and Complement disorders associated with primary immunodeficiencies. 

In-depth discussion of pathophysiologic mechanisms and examples of four major classes of hypersensitivity reactions; relevant for USMLE step 1 and USMLE step 2,3 

Review of different classes of immunologic agents such as monoclonal antibodies, Interleukin receptor agonists & antagonists and other agents with their clinical indications and side effect profile; prerequisite to this episode is the review of foundational basic science of immunosuppressive agents 

Following the format of conceptual / clinical understanding, Pathogenesis , Epidemiology & Risk Factors, followed by Clinical Findings, Diagnostic Workup and an important discussion of pharmacotherapy in gout and preventive measures.  

High Yield discussion for vaccination guidelines among patients with primary immunodeficiencies; 

We discuss the following disorders of adaptive immune system resulting in primary immunodeficiency: B-cell disorders: Agammaglobulinemia (including Bruton's), Selective IG deficiency (including selective IgA deficiency), Common Variable Immunodeficiency T-cell Disorders: DiGeroge, IL-12 receptor pathway disorders (Mendelian Susceptibility to Mycobacterial Infection), Chronic Mucocutaneous Candidiasis Combined B & T cell disorders: Severe combined immunodeficiency (SCID), Autosomal-...

These (HLH & ALPS) are the major syndromes of innate and adaptive immune dysregulation respectively resulting in primary immunodeficiency. For the discussion of complement system dysregulation refer to episode on innate immune deficiencies of innate immune system. Also compare HLH with MAS (macrophage activation syndrome) discussed in pharmacotherapy of Juvenile Rheumatoid Arthritis