Nuances of NCA (Ep. 5)
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Description
In this episode, I discuss some nuances of non-compartmental analysis or NCA. I am going to focus on three separate parameters: Cmax, AUC, and the terminal elimination rate constant. These three are the most commonly used parameters to describe drug exposure. I’ll discuss the basic methodology for each and then discuss challenges that may arise when you are performing an analysis.
Links discussed in the show:
Images mentioned in the podcast
Derivation of logarithmic AUC
Calculating the elimination rate constant
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