In this episode, we examine how the course of human history has shaped our scientific knowledge, why the physics community prioritizes some questions over others, and why progress in complex systems research is especially difficult. Academia continues to operate within set boundaries and students are taught certain concepts as fundamental and to skirt others completely. However, the history of science demonstrates that such concepts aren’t always set in stone. It’s possible that blowing open the “shackles of reality,” such as redefining the concept of life itself, and reprioritizing the problems that scientists want to tackle, might help scientists make more progress in this very difficult world of complexity research.