Neil McNeil talks to Kate Bingham, chair of the UK Vaccine Task Force, Dr. Jonathan Sheffield, National Institute for Health Research/Department of Health and Social Care COVID-19 Liaison Director for Research, and Dr. Phil Bryan, Head of Vaccine Safety at the Medicines and Healthcare Products Regulatory Agency, about how safety is controlled in the process of developing and testing a potential vaccine, and how to reassure people who may be reluctant to take a vaccine or volunteer for trials.