Dr Tine Sylvest Meyhoff (Copenhagen, Denmark) presents the results of the CLASSIC trial at the Critical Care Reviews Meeting 2022. Prof Katryn Maitland (Kalifi, Kenya) delivers an editorial, which is followed by a panel discussion including Prof David Harrison (London, England), Dr Lennie Derde (Utrecht, the Netherlands), Dr Jon Silversides (Belfast, Northern Ireland), and the chief investigator for CLASSIC, Prof Anders Perner (Copenhagen, Denmark). The session is chaired by Prof Bala Venkatesh from Brisbane, Australia.