John Myburgh and Ian Seppelt  (Sydney) present the results of the SuDDICU trial at the Critical Care Reviews Meeting 2022, in Titanic Belfast. SuDDICU investigates selective digestive decontamination in critically ill mechanically ventilated patients. Naomi Hammond (Sydney) follows with a presentation of a systematic review and meta analysis also on SDD. John Marshall (Toronto) delivers an editorial. Danny McAuley (Belfast), Bodil Steen Rasmussen (Aalborg) and Victoria Cornelius (London) join the presenters for a panel discussion. The session is chaired by Chris Seymour (Pittsburgh).