While the current global financial crisis has been dominating headlines recently, it is important not to neglect another complex and insufficiently regulated system: the nuclear non-proliferation and disarmament regime. CTBTO Spectrum 12 highlights the crucial role that the Comprehensive Nuclear-Test-Ban Treaty (CTBT) plays in this regime and is honoured to have an interview with the Academy Award-winning actor and UN Messenger for Peace, Michael Douglas, as well as articles by the German Foreign Minister, Frank-Walter Steinmeier, and the Norwegian Foreign Minister, Jonas Gahr Støre. Their contributions are complemented by articles from Deepti Choubey of the Nuclear Nonproliferation Program at the Carnegie Endowment for International Peace, and Raymond Jeanloz of the University of California, Berkeley. Spectrum 12 also outlines the build-up of the International Monitoring System over the last decade, the Integrated Field Exercise 2008 for on-site inspections, the International Scientific Studies project to assess the readiness and capability of the CTBT to detect nuclear explosions worldwide, and Part 2 of the ongoing cooperation between the CTBTO and the World Meteorological Organization.