Amyloid Disease: Are the oligomeric toxic species a good target for therapeutics?
Description
It is believed that in many amyloid diseases, including Alzheimer’s, the primary toxic species
responsible for neurodegeneration are small oligomers of the causative protein, rather
than the fibres that often define the disease. I have, therefore, isolated oligomers of our
model protein Cystatin B and those of Amyloid β in order to further characterise them.