Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update     discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting.   This issue will review: 1.     Long-term Weekly Icodec versus Daily Glargine U100 in Type 2 Diabetes without Previous Insulin 2.     Triple – Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial 3.     Effects of Tirzepatide Versus Insulin Glargine on Cystatin C–Based Kidney Function 4.     Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes Complications 5.    Tirzepatide Once Weekly for the Treatment of Obesity in People with Type 2 Diabetes (SURMOUNT-2): a Phase 3 Trial For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health