In this second episode in a two-part series on organ-on-a-chip technology, we sit down with Christos Michas, R&D scientist and engineer at Curi Bio, and Alice White, professor of mechanical engineering at Boston University. Christos and Alice are taking the organ on a chip to another level with the miniPUMP, a heart on a chip which is the first step in understanding the interaction of therapeutic drugs with the heart. As cardiac disease is one of the leading causes of death in the industrialized world, there is a lot of interest in understanding how this disease emerges, and how we can develop therapeutics. Show notes Christos Michas and Alice White et al. (2022) ‘Engineering a living cardiac pump on a chip using high-precision fabrication’, Science Advances 8(16). DOI: https://doi.org/10.1126/sciadv.abm3791. Keywords: organ on a chip, chip, cells, organ, heart, technology, tissue, structural elements, challenge, structure, model, drugs, photon, system, resin, material, function, miniPUMP.