GUEST: Kevin Brindle, Cambridge In this episode we welcome the one and only Kevin Brindle from University of Cambridge. During his long and illustrious career, Kevin pioneered hyperpolarized magnetic resonance spectroscopy as a method to map metabolic flux in cancer and other diseases, with implications for treatment response monitoring. We explore how deuterium imaging and [18F]FDG PET can be used to track the metabolic changes that occur soon after stroke and during the recovery phase. We discuss the complementary information that these two techniques provide and whether they could be used to improve clinical outcomes. Along the way, we learn how Kevin could have worked in structural biology or been a painter and decorator... and how he used to meet his wife-to-be in the cold room when he was a postdoc at Oxford. Selected Publication: In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status - A pilot study combining PET and deuterium metabolic imaging. Meerwaldt AE, Straathof M, Oosterveld W, van Heijningen CL, van Leent MM, Toner YC, Munitz J, Teunissen AJ, Daemen CC, van der Toorn A, van Vliet G, van Tilborg GA, De Feyter HM, de Graaf RA, Hol EM, Mulder WJ, Dijkhuizen RM. J Cereb Blood Flow Metab. 2023 May;43(5):778-790. doi: 10.1177/0271678X221148970. Epub 2023 Jan 6. https://journals.sagepub.com/doi/10.1177/0271678X221148970 Further information on the European Society for Molecular Imaging: https://e-smi.eu/ Contact: [email protected]