Join orthopedic surgeons Dr. Alan Rechter and Dr. Alex Sah for an engaging conversation about improved pain relief and reduction of opioids and narcotics provided by ZYNRELEF ® (bupivacaine and meloxicam) extended-release solution used in conjunction with joint arthroplasty surgery.  Heron Therapeutics received an FDA approval of a significant indication expansion for ZYNRELEF on December, 9 2021. This label expansion now indicates ZYNRELEF for the postoperative pain treatment of adults for soft tissue or periarticular instillation to produce postsurgical analgesia for up to 72 hours after foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures. For more information, please visit: https://zynrelef.com/  For safety information, please visit: https://zynrelef.com/prescribing-information.pdf    Please see below for Important Safety Information ZYNRELEF is approved for use in adults to reduce pain for up to 3 days after foot and ankle surgeries, small-to-medium open abdominal surgeries, and total joint replacement surgeries of the lower extremity. ZYNRELEF is applied into the wound at the time of surgery. Important Safety Information ZYNRELEF contains an NSAID (non-steroidal anti-inflammatory drug), a type of medicine which: Can increase the risk of a heart attack or stroke that can lead to death. This risk increases with higher doses and longer use of an NSAID Cannot be used during heart bypass surgery. Can increase the risk of gastrointestinal bleeding, ulcers, and tears. ZYNRELEF should also not be used: if you are allergic to any component of ZYNRELEF, similar local anesthetics, aspirin or other NSAIDs (such as ibuprofen or naproxen), or have had an asthma attack, hives, or other allergic reaction after taking any of these medicines. as a paracervical block, during childbirth. The most common side effects of ZYNRELEF are constipation, vomiting, and headache. The medicines in ZYNRELEF (a local anesthetic and an NSAID) may affect the nervous and cardiovascular system; may cause liver or kidney problems; may reduce the effects of some blood pressure medicines; should be avoided if you have severe heart failure; may cause adverse effects on cartilage; may cause a rare blood disorder, or life-threatening skin or allergic reactions; may harm your unborn baby if received at 20 weeks of pregnancy or later; and may cause low red blood cells (anemia). Tell your healthcare provider about all your medical conditions and about all the medicines you take including prescription or over-the-counter medicines, vitamins, or herbal supplements to discuss if ZYNRELEF is right for you. Talk to your healthcare provider for medical advice about side effects. Report side effects to Heron at 1-844-437-6611 or to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. The information provided here is not comprehensive. Please see full Prescribing Information, including Boxed Warning.