We are in the midst of a significant change in transfusion medicine. Trauma centers all over are starting to replace blood product components with the use of whole blood for massive bleeds. Bennett Sorensen from OHSU talks to Dr. Mark Yazer from the University of Pittsburgh about the historic changes in transfusion medicine and why there has been a recent revolution in the use of whole blood. Dr. Yazer reflects on the promises and limitations of whole blood as well as the need for further research.