Endo Voices welcomes dynamic and disruptive thought leader Dr. John Khademi to insightfully illustrate the paradigm shift contemporary endodontics has seen through unprecedented advancements in technology, concepts and materials. We unpack Endodontics 1.0, moreover, the mechanical objectives and the limitations of process-based outcomes set against the backdrop of biologic/radiographic outcomes. We push the envelope of discussion and evaluate the consequences of weakening of the tooth that convenience-driven straight-line access and obturation-driven shapes created and intertwine principles of "incommensurability”, showcasing how the art and science of endo need to abandon previous principles to predictably progress forward. Dr. Khademi’s uncanny wit and piercing intellect paint a permeating story of the evolution of technological incorporation, which facilitates the optimum marriage of proper instrumentation and irrigants propelled by fluid dynamics to eradicate intra-radicular infection at the highest biological level. Tap in today and discover how the best parts of Endodontics 3.0 are yet to come! Episodes of Endo Voices may include opinion, speculation and other statements not verifiable in the scientific method and do not necessarily reflect the views of AAE or the sponsor(s). Listeners should use their best judgment in evaluating the merits of any content. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.