In our enlightening discussion with Dr. Paul Rosenberg, esteemed professor and former chair of the NYU Endodontics Department, we explore a plethora of intriguing topics, including differential distinctions between vital and non-vital flare-ups, the judicious use of antibiotics, and the efficacy of occlusal reduction. Furthermore, Dr. Rosenberg sheds light on classic and emerging trends chronicling the utilization of supplemental bupivacaine and long-lasting local anesthetics. His discussion on the potential influence of genetics on treatment outcomes and the evolving understanding of calcium hydroxide's interaction with the immune system underscores his commitment to staying abreast of cutting-edge developments. Episodes of Endo Voices may include opinion, speculation and other statements not verifiable in the scientific method and do not necessarily reflect the views of AAE or the sponsor(s). Listeners should use their best judgment in evaluating the merits of any content. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.