Mental health disorders occur across geographic, socioeconomic, cultural, and ethnic boundaries and disproportionately affect young people. Although they are the leading cause of disability in countries at all levels of wealth, vast numbers of people lack access to appropriate care, partly due to inequities in funding and human resources and to the low priority given to mental health services. But new cadres — teams of mothers, lay health workers, and specialists — are extending the mental health workforce and helping to deliver treatments that work. How can we bring more of what works to more settings? Pamela Collins, associate director for special populations at the National Institute of Mental Health, explains why innovation with evidence should drive global engagement and revive the commitment to mental health.