Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-337 Overview: There has been uncertainty as to the best time for patients to take blood pressure medications. Tune in as we review the Treatment in Morning versus Evening (TIME) study, which assessed whether morning or evening dosing improves cardiovascular outcomes. Episode resource links: Mackenzie IS, Rogers A, Poulter NR, et al. Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial. Lancet. 2022;400(10361):1417-1425.  Guest: Alan M. Ehrlich MD, FAAFP Music Credit: Richard Onorato