Open-source data and artificial intelligence are poised to transform the health care landscape. Andrea Fletcher, chief digital strategy officer at the Centers for Medicare and Medicaid Services (CMS), aims to leverage and inject human-centered design into these concepts as the agency explores their potential for improving the quality of health care services and keep data secure in heightened threat environments. At HIMSS in Orlando, Florida, Fletcher provides a glimpse into some of the pilots her team has launched and where she sees opportunities for partnerships across the department to thrive.