TKI Toxicities: A Society of Gynecologic Oncology Podcast Moderator: Róisín O’Cearbhaill, MD, Gynecologic Medical Oncologist, Memorial Sloan Kettering Cancer Center, New York Speakers: BJ Rimel, MD, Gynecologic Oncologist, Cedars-Sinai Medical Center Erin Crane, MD, MPH, Gynecologic Oncologist, Levine Cancer Institute Vicky Makker, MD, Medical Oncologist, Memorial Sloan Kettering Cancer Center Jennifer MacDonald, PharmD, Oncology Clinical Pharmacy Specialist, Medical University of South Carolina Róisín O’Cearbhaill, MD, is joined by BJ Rimel, MD, Erin Crane, MD, MPH, Vicky Makker, MD, and Jennifer McDonald, PharmD, to review the clinical management of tyrosine kinase inhibitors (TKIs) in gynecologic cancers with consideration for dose adjustments and modifications. The speakers discuss the optimal management of commonly encountered toxicities, such as hypertension and hypothyroidism, that are associated with several of the TKIs. They also highlight management strategies, patient reference materials and anticipatory prescriptions for antihypertensives, antidiarrheals, and antiemetics. The podcast includes two patient cases that delve into information about the differences in toxicities between lenvatinib and pazopanib, hypertension and which drugs to use in which order (both starting dose and dose adjustments), and medical access and lab intervals. These practical clinical pearls in managing toxicities aim to guide practitioners on how best to use these drugs to treat gynecologic cancers. This podcast was developed by the Society of Gynecologic Oncology for Gynecologic Oncology. Additional Resources: Tyrosine kinase inhibitor toxicities: A Society of Gynecologic Oncology review and recommendations Download audio Browse all Gynecologic Oncology audio