IN THIS EPISODE: In this podcast episode, host Philip Guarino speaks with Andrew Lo, a distinguished professor at MIT and an entrepreneur with a focus on healthcare and deep tech ventures. Andrew shares his journey from academia to entrepreneurship, detailing his transition from economics to founding a quantitative investment firm and later exploring the financial challenges of drug development. He discusses the fundraising challenges for deep tech entrepreneurs, how investors’ risk calculation differs for more complex ventures and how this requires continuous investor communication and learning. Lo also highlights the vibrant innovation ecosystem in the Boston-Cambridge area and his passion for mentoring students in entrepreneurial projects. GUEST BIO: Andrew W. Lo is the Charles E. and Susan T. Harris Professor at the MIT Sloan School of Management, director of MIT’s Laboratory for Financial Engineering, and principal investigator at MIT's Computer Science and Artificial Intelligence Laboratory. He is a co-founder and director of BridgeBio Pharma, a director of AbCellera, Atomwise, and Vesalius, a co-founder and chairman of QLS Advisors, and a member of the advisory board to the American Cancer Society’s BrightEdge Impact Fund. Dr. Lo received his B.A. in economics from Yale University and his A.M. and Ph.D. in economics from Harvard University.