Join the H-Hour community today on Discord: https://discord.gg/ncFRpvTkjX ***** Dr Simon Ruffell is a Psychiatrist & Senior Research Fellow and co-founder of Onaya Science. Dr WaiFung Tsang is a Clinical Psychologist and co-founder of Onaya Science. This conversation explores the research and therapeutic potential of ayahuasca, a psychedelic brew used in indigenous communities in South America. The discussion covers topics such as epigenetic changes, the long-term effects of ayahuasca, the gut-brain connection, and the involvement of indigenous communities in research. The conversation also touches on the challenges of conducting research in a shamanic and ritualistic context and the perception of ayahuasca research in the scientific community. This conversation explores various aspects of ayahuasca and its impact on spiritual practices, the benefits of plant medicine and Chinese medicine, the availability and variations of ayahuasca, research on ayahuasca-like compounds, the selection of the Shipibo community for retreats, the journey of research and learning in ayahuasca, the Amazon as an unknown cradle of civilization, future research and expansion of studies, exploring ayahuasca and traumatic brain injury, the changing perception of psychedelics in society, Onaya's website and training programs, and funding and support for Onaya's research.