Fully understanding and regulating our complex information ecosystems will require creating new cultures and modes of collaborating, new organizational frameworks and, yes, working with generative AI models in service of aggregating actionable scientific knowledge. Angela Aristidou (CASBS fellow, 2022-23) thinks through the crucial questions and challenges with Phil Howard (CASBS fellow, 2008-09), a renowned scholar of tech innovation and public policy as well as co-founder and chair of the new International Panel on the Information Environment (IPIE).