While advanced monitoring technology can provide valuable information, the importance of clinical judgment and examination should not be minimized. Host Ludwig H. Lin, MD, is joined by Maurizio Cecconi, MD, to discuss the integration of clinical judgment with technology when assessing hemodynamic instability and shock. They emphasize the importance of fluid challenges tailored to individual patient characteristics, along with standardized approaches. Dr. Cecconi explores the role of big data and artificial intelligence (AI) in treatment refinement and advocates for global access to care. He highlights fluid responsiveness dynamics and the interaction between fluids and vasopressors, urging a cautious approach to fluid administration due to its drug-like effects. Dr. Cecconi is an anesthesiologist and intensive care specialist and chair of the Department of Anesthesia and Intensive Care at Humanitas Research Hospital and University in Milan, Italy. This podcast is sponsored by Baxter Healthcare.